BioPOLIM - Nanoscale infrared spectroscopic imaging (NanIR)

projects & grants
Logo_HiResi4RPE DFG logo

DFG project funding Ta 1049/4 High resolution fluorescence lifetime and infrared spectroscopic characterization of pathogenic retinal pigment epithelium cell organelles (HiResi4RPE) (September 2024 - August 2027) for Daniela Täuber at the Institute of Physical Chemistry, Nanoimaging (Nanobiophotonics) Group, Friedrich Schiller University, Jena. Joint project with Rainer Heintzmann, Microscopy Department, Leibniz Institute of Photonic Technology, Jena and with Martin Hammer, Experimental Ophthalmology Jena University Hospital.

Funded by European Union

European Union Cost Action Ca21111 OneHealtdrugs for Vector-borne Diseases (10/22-09/26), Member of WG 2&3, Conference Funding: 03-05 July 2024 Advancements in Structural and Functional Drug Discovery of Vector-borne Diseases.

Project: pintXsum (10/22-09/23) Photo-INduced Thermal eXpansion of rough SUrface Morphologies by the Friedrich-Schiller University Jena in the Profile line "Light" together with Christin David, FSU Jena.

ThuringianMinistry

Postdoctoral Scholarship by the Friedrich-Schiller University Jena (12/19-05/20): POLIRIM Fortführung von grundlegenden Untersuchungen mit polarisationsaufgelöster IR-Spektroskopie und photo-induzierter Rasterkraftmikroskopie (PiFM) für biomedizinische Anwendung (Continued fundamental investigation using polarization resolved IR spectroscopy and photo-induced force microscopy for biomedical application) in the Nanoimaging (Nanobiophotonics) Group of Rainer Heintzmann, granted in the context of Thuringia's program for support of female junior researchers and junior artists.

methods
  • Mid Infrared Photo-induced Force Microscopy (PiF-IR, IR-PiFM)
  • Tapping Atomic Force Microscopy Infrared Spectroscopy (tapping AFM-IR)
  • Optical Photo-thermal Infrared Spectroscopy (O-PTIR)
areas of research

NanIR method evaluation and development

PiF-IR on spherical NP, TOC Graphics JPPC2025 doi:10.1021/acs.jpcc.4c08305
  • S. Anindo, D. Täuber, C. David >Photothermal Expansion of Nanostructures in Photo-induced Force Microscopy, J. Phys. Chem. C, 129, 4517, 2025. doi:10.1021/acs.jpcc.4c08305 arXiv:2412.04897
  • D. Täuber, R. Schneider, C. Krafft, U. Hübner, R. Heintzmann, and T.G. Mayerhöfer: Interference effects in nanoscale infrared spectroscopy methods, in revision.
  • S. Anindo, R. Heintzmann, D. Täuber, C. David Photo-thermal Expansion of a nanostructured surface in Photo-induced Force Microscopy (PiFM), Nano-Scientific Forum Europe NSFE2023, Barcelona, Spain, September 2023. doi:10.13140/RG.2.2.10065.92003
  • S. Barua, H. Gadher, U. Hübner, D. Täuber, Topological artifacts in mid-IR photo-induced force microscopy (PiF-IR). DPG conference, Regensburg, September 2022. doi:10.13140/RG.2.2.12791.29609
  • N. Krishnakumar, A. Strecker, M. Luo, R. Lachmann, R. Heintzmann, P. Biehl, F.H. Schacher, U. Neugebauer, D. Täuber, Insights from application of photo-induced force microscopy (PiFM) for investigation of multicore magnetic nanoparticles (MCNPs). 2020 NanoScientific Forum Europe, September 2020. Poster Presentation, doi:10.13140/RG.2.2.13191.06564
  • N. Krishnakumar, A. Strecker, P. Biehl, F.H. Schacher, A.-D. Müller, A. Ramoji, U. Neugebauer, D. Täuber, Nanoscale chemical imaging of cell surface and core-shell nanoparticles using infrared excitation and detection by force microscopy. 70th Moosbacher Kolloquium, Moosbach, April, 2019. doi:10.13140/RG.2.2.20000.25601
Collaborations:
  • U. Neugebauer, F.H. Schacher, P. Biehl, N. Krishnakumar, A. Strecker
  • R. Lachmann, M. Luo, R. Heintzmann
  • M. Presselt, M. Hupfer, S.J. Finkelmeyer, R. Schneider
  • R. Schneider, C. Krafft, K. Pippardt, U. Hübner, T. Mayerhöfer, R. Heintzmann
  • J. Joseph, S. Anindo, C. David

Application of NanIR for biomedical investigation

Distribution of drug in tissue
  • M. Ali, R. Schneider, A. Strecker, N. Krishnakumar, S. Unger, M. Soltaninezhad, J. Kirchhoff, A. Tannert, K. A. Dragounova, R. Heintzmann, A.-D. Müller, C. Krafft, U. Neugebauer, D. Täuber: Subcellular nano-chemical characterization in photother- mal spectroscopic imaging of antimicrobial interaction in model system Bacillus subtilis & vancomycin, submitted, 2025. arXiv:2505.10249
  • J. Joseph, L. Spantzel, M. Ali, D.M. Joseph, S. Unger, K. Reglinski, C. Krafft, A.-D. Müller, C. Eggeling, R. Heintzmann, M. Börsch, A.T. Press, D. Täuber Nanoscale chemical characterization of secondary protein structure of F-Actin using mid-infrared photoinduced force microscopy (PiF-IR). Spectrochimica Acta part A: Molecular and Biomolecular Spectroscopy, 306, 123612, 2024. doi:10.1016/j.saa.2023.123612
  • D. Täuber, S. Unger, P. Then, R. Heintzmann, T. Ach, Ex-vivo application of IR-spectroscopic force microscopy to granules of the human retinal pigment epithelium. Women in Photonics 2020, October 2020. abstract
Collaborations:
  • A.T. Press, M. Babic, K-J. Benecke, et al.
  • U. Neugebauer, R. Schneider, A. Strecker, et al.
  • T. Ach, M. Ali, M. Soltaninezhad, S. Unger, P. Then, R. Heintzmann

Application of NanIR to (bio)polymers

Orientation of polymer chains in film
  • X. Luo, Y. Xue, W. Cai, D. Täuber, I. Malovicho, B. Sava, L. Ma, G. Cen, X. Lu, C. Zhao, I.G. Scheblykin, J. Yu, W. Mai, F. Liu, E. Wang, L. Hou: Intrinsic Polarization-Sensitive Organic Photodetector with Self-Assembled All-Polymer Heterojunction, Applied Physics Letters, 121, 233301, 2022. doi:10.1063/5.0128850.
  • B. Aráoz, N.J. Lorez, D. Täuber, A.R. Boccaccini, G.A. Abraham, P.C. Caracciolo, E.B. Hermida, Study on the morphology and mechanical properties of filaments composed of poly(ester urethane)/poly(3-hydroxybutyrate-co-3-hydroxyvalerate)/bioglass for 3D-printing applications in tissue engineering. XIX Brazil MRS Meeting, September 2021.
Collaborations:
  • B. Aráoz et al.
  • W. Cai et al.
collaboration
Department of Ophthalmology, University Hospital Bonn Department of Ophthalmology, University Hospital Bonn, Germany
Nanophysiology group Nanophysiology, Jena University Hospital, Germany
Center for Sepsis Control and Care Center for Sepsis Control & Care, Jena University Hospital, Germany
Funded by European Union COST Action CA21111 OneHealthdrugs
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